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KMID : 0366220060410040302
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Korean Journal of Hematology
2006 Volume.41 No. 4 p.302 ~ p.305
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A Case of Acute Promyelocytic Leukemia after Iodine-131 Treatment for Thyroid Cancer
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Lee Sang-Hun
Eom Ki-Seong
Lee Seok
Kim Hee-Je
Min Chang-Ki
Kim Sung-Yong
Cho Byung-Sik
Lee Hyuck
Park Chan-Kwon
Cho Seok-Goo
Kim Dong-Wook
Lee Jong-Wook
Min Woo-Sung
Kim Chun-Choo
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Abstract
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Radioactive iodine (131I) has been used in the treatment of thyroid cancer to eliminate residual thyroid tissue after thyroidectomy and to treat metastatic disease. Leukemia has rarely been reported as a late complication of 131I therapy, occurring most frequently after receiving a cumulative activity of 800 mCi of the radioisotope. Although FAB M3 type (acute promyelocytic leukemia, APL) as the secondary acute leukemia had been rarely reported, recently there have been a few cases of therapy-related APL leukemia seen. We hereby report a case of secondary acute promyelocytic leukemia occurring in a patient who received radioactive iodine therapy for papillary thyroid carcinoma. An assessment of causality using the Naranjo probability scale showed that a possible relationship existed between APL seen in the patient and the use of the radioactive iodine. Although this is a very rare event, strict hematologic follow-up of patients treated with radioactive iodine may be warranted, along with a high index of suspicion in those with coagulopathy.
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KEYWORD
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Acute promyelocytic leukemia, Radioactive iodine, Secondary AML
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